Lamotrigina y su relación con el síndrome de Stevens-Johnson y la necrólisis epidérmica tóxica

Lamotrigine is an antiepileptic drug that has been widely used for epilepsy, as a mood stabilizer (for type 1 bipolar disorder) and in the management of neuropathic pain, it both monotherapy complementary therapy. Considered relatively new, approved by Food Drug Administration 1994, its benefits include greater margin safety compared to other anticonvulsants. However, although lower percentage, causes severe adverse skin reactions such Stevens-Johnson syndrome toxic epidermal necrolysis. A review made about probable pathways trigger this delayed hypersensitivity immune response.